This guide is built on insights from 56 Southern U.S. business school leaders, revealing the urgency and practicality of AI integration in higher education. It outlines the common challenges—such as faculty resistance and evolving accreditation demands—while providing a structured framework for introducing AI literacy, fostering faculty development, aligning with industry trends, and upholding ethical standards. The recommendations span immediate curriculum updates and longer-term strategic planning, making the guide an indispensable resource for any institution seeking to remain competitive and relevant.